| 1. Identity statement | ||||
| Reference Type | Journal Article | |||
| Site | mtc-m21b.sid.inpe.br | |||
| Holder Code | isadg {BR SPINPE} ibi 8JMKD3MGPCW/3DT298S | |||
| Identifier | 8JMKD3MGP3W34P/3M3ADKH | |||
| Repository | sid.inpe.br/mtc-m21b/2016/07.08.12.52 (restricted access) | |||
| Last Update | 2016:07.08.12.53.34 (UTC) simone | |||
| Metadata Repository | sid.inpe.br/mtc-m21b/2016/07.08.12.52.15 | |||
| Metadata Last Update | 2024:05.08.19.53.59 (UTC) simone | |||
| DOI | 10.2147/IJN.S106339 | |||
| ISSN | 1176-9114 | |||
| Citation Key | RodriguesLCSMCWL:2016:ChBiEv | |||
| Title | Graphene oxide/multi-walled carbon nanotubes as nanofeatured scaffolds for the assisted deposition of nanohydroxyapatite: characterization and biological evaluation  | |||
| Year | 2016 | |||
| Month | June 13 | |||
| Access Date | 2024, May 19 | |||
| Type of Work | journal article | |||
| Secondary Type | PRE PI | |||
| Number of Files | 1 | |||
| Size | 6735 KiB | |||
| 2. Context | ||||
| Author | 1 Rodrigues, Bruno V. M. 2 Leite, Nelly C. S. 3 Cavalcanti, Bruno das Neves 4 Silva, Newton S. da 5 Marciano, Fernanda R. 6 Corat, Evaldo José 7 Webster, Thomas J. 8 Lobo, Anderson de Oliveira | |||
| Resume Identifier | 1 2 3 4 5 6 8JMKD3MGP5W/3C9JH33 | |||
| Group | 1 2 3 4 5 6 LAS-CTE-INPE-MCTI-GOV-BR | |||
| Affiliation | 1 Universidade do Vale do Paraíba (UNIVAP) 2 Universidade do Vale do Paraíba (UNIVAP) 3 University of Michigan 4 Universidade do Vale do Paraíba (UNIVAP) 5 Universidade do Vale do Paraíba (UNIVAP) 6 Instituto Nacional de Pesquisas Espaciais (INPE) 7 Northeastern University 8 Universidade do Vale do Paraíba (UNIVAP) | |||
| Author e-Mail Address | 1 2 3 4 5 6 evaldo.corat@inpe.br | |||
| Journal | International Journal of Nanomedicine | |||
| Volume | 11 | |||
| Pages | 2569-2585 | |||
| Secondary Mark | A2_FARMÁCIA A2_CIÊNCIAS_BIOLÓGICAS_I B1_MEDICINA_I B1_CIÊNCIAS_BIOLÓGICAS_II B1_ASTRONOMIA_/_FÍSICA C_QUÍMICA C_BIOTECNOLOGIA | |||
| History (UTC) | 2016-07-08 12:53:34 :: simone -> administrator :: 2016 2018-06-04 02:40:59 :: administrator -> simone :: 2016 | |||
| 3. Content and structure | ||||
| Is the master or a copy? | is the master | |||
| Content Stage | completed | |||
| Transferable | 1 | |||
| Content Type | External Contribution | |||
| Version Type | publisher | |||
| Keywords | Bactericidal effect Bioactivity Bone cells Graphene oxide In vitro Multi-walled carbon nanotubes Nanohydroxyapatite Tissue engineering | |||
| Abstract | Nanohydroxyapatite (nHAp) is an emergent bioceramic that shows similar chemical and crystallographic properties as the mineral phase present in bone. However, nHAp presents low fracture toughness and tensile strength, limiting its application in bone tissue engineering. Conversely, multi-walled carbon nanotubes (MWCNTs) have been widely used for composite applications due to their excellent mechanical and physicochemical properties, although their hydrophobicity usually impairs some applications. To improve MWCNT wettability, oxygen plasma etching has been applied to promote MWCNT exfoliation and oxidation and to produce graphene oxide (GO) at the end of the tips. Here, we prepared a series of nHAp/MWCNT-GO nanocomposites aimed at producing materials that combine similar bone characteristics (nHAp) with high mechanical strength (MWCNT-GO). After MWCNT production and functionalization to produce MWCNT-GO, ultrasonic irradiation was employed to precipitate nHAp onto the MWCNT-GO scaffolds (at 13 wt%). We employed various techniques to characterize the nanocomposites, including transmission electron microscopy (TEM), Raman spectroscopy, thermogravimetry, and gas adsorption (the BrunauerEmmettTeller method). We used simulated body fluid to evaluate their bioactivity and human osteoblasts (bone-forming cells) to evaluate cytocompatibility. We also investigated their bactericidal effect against Staphylococcus aureus and Escherichia coli. TEM analysis revealed homogeneous distributions of nHAp crystal grains along the MWCNT-GO surfaces. All nanocomposites were proved to be bioactive, since carbonated nHAp was found after 21 days in simulated body fluid. All nanocomposites showed potential for biomedical applications with no cytotoxicity toward osteoblasts and impressively demonstrated a bactericidal effect without the use of antibiotics. All of the aforementioned properties make these materials very attractive for bone tissue engineering applications, either as a matrix or as a reinforcement material for numerous polymeric nanocomposites. | |||
| Area | FISMAT | |||
| Arrangement | urlib.net > BDMCI > Fonds > Produção anterior à 2021 > LABAS > Graphene oxide/multi-walled carbon... | |||
| doc Directory Content | access | |||
| source Directory Content | there are no files | |||
| agreement Directory Content |
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| 4. Conditions of access and use | ||||
| Language | en | |||
| Target File | rodrigues_graphene.pdf | |||
| User Group | simone | |||
| Reader Group | administrator simone | |||
| Visibility | shown | |||
| Read Permission | deny from all and allow from 150.163 | |||
| Update Permission | not transferred | |||
| 5. Allied materials | ||||
| Mirror Repository | urlib.net/www/2011/03.29.20.55 | |||
| Next Higher Units | 8JMKD3MGPCW/3ESR3H2 | |||
| Citing Item List | sid.inpe.br/bibdigital/2013/09.24.19.30 3 sid.inpe.br/mtc-m21/2012/07.13.14.45.37 3 | |||
| Dissemination | WEBSCI; PORTALCAPES; SCOPUS. | |||
| Host Collection | sid.inpe.br/mtc-m21b/2013/09.26.14.25.20 | |||
| 6. Notes | ||||
| Empty Fields | alternatejournal archivingpolicy archivist callnumber copyholder copyright creatorhistory descriptionlevel e-mailaddress format isbn label lineage mark nextedition notes number orcid parameterlist parentrepositories previousedition previouslowerunit progress project rightsholder schedulinginformation secondarydate secondarykey session shorttitle sponsor subject tertiarymark tertiarytype url | |||
| 7. Description control | ||||
| e-Mail (login) | simone | |||
| update | ||||